科研级贝利西单抗——Research Grade Blisibimod（DHJ85305）

一、产品概述

尊龙凯时推出的Research Grade Blisibimod（科研级贝利西单抗）是一种高品质的蛋白抗体试剂盒，专为科研用途设计。Blisibimod（A623）作为一种有效的选择性四价B细胞激活因子（BAFF）抑制剂，广泛应用于系统性红斑狼疮（SLE）的研究中。

二、产品详情

产品名称：Research Grade Blisibimod（科研级贝利西单抗）
货号：DHJ85305
表达系统：哺乳动物细胞
种属反应性：人类
宿主：人类
同种型：Fusion-[peptide 16-mer-peptide 19-mer]2-IGHG1Fc（Fragment constant）
靶标：BAFF, ZTNF4, BLYS, 肿瘤坏死因子配体超家族成员13B, 树突状细胞衍生的TNF样分子, TALL-1, TNF和APOL相关白血球表达配体1, BLyS, B淋巴细胞刺激因子, TNFSF13B, CD257, TNFSF20, TALL1, B细胞活化因子
浓度：0.5 mg/ml
内毒素水平：请联系实验室获取信息
纯度：95%（根据SDS-PAGE分析）
纯化方式：通过蛋白A/G从细胞培养上清中纯化
Accession号：Q9Y275
克隆号：Blisibimod
应用：Research Grade Biosimilar
状态：液体
保存溶液：0.01 M PBS, pH 7.4
稳定性和存储：使用手动解冻冰箱，避免反复冻融。短期存储在4°C（1-2周），长期存储在-20°C（12个月），在-80°C保存可保持更长时间
别名：A–623

三、参考文献

1. Blisibimod for treatment of systemic lupus erythematosus: with trials, you become wiser (PMID: 27051973)
2. Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date (PMID: 28331294)
3. A narrative review of potential drug treatments for nephritis in children with IgA vasculitis (HSP) (PMID: 37755547)
4. The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity (PMID: 23684423)
5. Advances in natural products and antibody drugs for SLE: new therapeutic ideas (PMID: 37492083)
6. Emerging B-Cell Therapies in Systemic Lupus Erythematosus (PMID: 33488082)
7. Phase III trial results with blisibimod, a selective inhibitor of B-cell activating factor, in subjects with systemic lupus erythematosus (SLE): results from a randomized, double-blind, placebo-controlled trial (PMID: 29563108)
8. Treatment of systemic lupus erythematosus patients with the BAFF antagonist "peptibody" blisibimod (AMG623/A-623): results from randomized, double-blind phase 1a and phase 1b trials (PMID: 26290435)
9. A phase 2, randomized, placebo-controlled clinical trial of blisibimod, an inhibitor of B cell activating factor, in patients with moderate-to-severe systemic lupus erythematosus: the PEARL-SC study (PMID: 24748629)
10. Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus (PMID: 24521424)

四、联系方式

如需了解更多信息，请咨询尊龙凯时中国地区授权总代理——武汉佰乐博生物科技有限公司。该公司作为法国Antibody system品牌在亚洲区的授权总代理，提供近3万种蛋白、抗体等核心生命科学试剂，致力于为生命科学研究者提供专业、全面、可靠的试剂产品。

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